Published Research
CLINICAL EVIDENCE
The benefits of nano-hydroxyapatite and xylitol are documented across peer-reviewed clinical trials and systematic reviews. Here are the highlights.
A selection of peer-reviewed studies on nano-hydroxyapatite and xylitol. Renamel® is a cosmetic product and this information is provided for education only.
Remineralisation · lab
143% enamel hardness recovery vs 116% for fluoride
In laboratory testing of demineralised enamel, nano-hydroxyapatite restored more surface hardness than a fluoride-only treatment under the same test conditions.
Ebadifar et al., 2017 (7% nano-hydroxyapatite) · see bibliography →
Cavity prevention · 18-month RCT
89.3% of hydroxyapatite users had no cavity increase, vs 87.4% with fluoride
An 18-month head-to-head trial found hydroxyapatite toothpaste comparable to fluoride for caries prevention.
Paszyńska et al., 2023 (double-blind randomised controlled trial) · see bibliography →
Sensitivity · systematic review
Better desensitising effect than other treatments
Across multiple clinical trials, nano-hydroxyapatite showed a better desensitising effect and clinical performance by sealing exposed dentinal tubules.
de Melo Alencar et al., 2019 (review of 6 clinical trials) · see bibliography →
Whitening · systematic review
Effective whitening through a dual mechanism — no bleaching chemicals
Surface smoothing plus a built-up micro-layer brighten teeth without peroxide and without the sensitivity associated with bleaching.
Limeback, Meyer & Enax, 2023 (review of 17 studies) · see bibliography →
Microbiome · xylitol
A "legacy effect": fewer new cavities up to 2 years after stopping use
Children using high-dose xylitol for six months had significantly fewer new cavities even two years after discontinuing — alongside reported reductions in plaque and mutans streptococci.
Campus et al., 2013 · see bibliography →
Mechanism · microscopy
Direct evidence of mineral deposition into damaged enamel
Imaging showed nano-hydroxyapatite particles depositing into damaged tooth areas, with significantly higher remineralisation capability than fluoride in the same study.
Juntavee et al., 2018 (electron microscopy) · see bibliography →
Reported nano-hydroxyapatite studies have also described reductions in oral bacterial load of up to 65%. Want the detail behind every figure on this page?
Disclaimer: Renamel® is a cosmetic product. Research information is for educational purposes only. Individual results may vary. Consult your dental professional.
