The Science of Renamel

Discover the compelling evidence behind our revolutionary ingredients—nano‑hydroxyapatite and xylitol—that are transforming oral care with proven results from clinical trials worldwide.

Nano‑Hydroxyapatite vs. Fluoride: Head‑to‑Head Studies

The gold standard of dental research—long‑term clinical trials—shows nano‑hydroxyapatite achieving comparable caries outcomes to fluoride, making it a compelling fluoride‑free alternative backed by rigorous science.

• Pawinska et al., 2024 — Updated systematic review and meta‑analysis found people using hydroxyapatite toothpaste were 2.51 times more likely to prevent dental caries compared to placebo, with a slight edge over fluoride (odds ratio 1.1 in favour of HAP). Study Link
• Wierichs et al., 2022 — Comprehensive systematic review found that under remineralising conditions (like normal saliva flow), nano‑hydroxyapatite showed the same remineralising potential as fluoride, supporting its use as an effective alternative. Study Link

Superior Remineralisation: Rebuilding Tooth Structure

Nano‑hydroxyapatite doesn't just match fluoride—multiple studies show it can outperform fluoride for enamel remineralisation and hardness recovery in laboratory testing, actively rebuilding tooth structure at the molecular level.

• Juntavee et al., 2018 — Nano‑hydroxyapatite gel demonstrated "significantly higher capability for remineralisation" on both enamel and the tooth root surface compared to fluoride cream, with electron microscope images showing n-HAp particles directly depositing into damaged areas. Study Link
• Tschoppe et al., 2011 — Nano‑hydroxyapatite toothpastes showed higher remineralising effects on dentine compared to fluoride toothpaste, with the higher pH of n-HAp (6.94–7.39 vs fluoride's 5.24) appearing to favour deeper repair. Study Link

Rapid Sensitivity Relief: Clinically Demonstrated Results

Tooth sensitivity affects millions, but nano‑hydroxyapatite offers effective relief by physically sealing the microscopic channels that cause discomfort—with clinical studies showing significant improvements in just 2‑4 weeks.

• de Melo Alencar et al., 2019 — Systematic review and meta‑analysis of six randomised clinical trials found nano‑hydroxyapatite showed "better desensitising effect" for both air blast and touch stimuli compared to other approaches, concluding "better clinical performance than other treatments for sensitivity relief." Study Link
• Hu et al., 2018 — Meta‑analysis of 53 randomised controlled trials confirmed nano‑hydroxyapatite toothpastes are effective in relieving sensitivity symptoms by physically blocking dentine tubules, offering a different mechanism than potassium‑based approaches. Study Link

Natural Whitening: Beauty Through Restoration

Unlike harsh bleaching chemicals, nano‑hydroxyapatite whitens teeth by restoring their natural structure—filling micro‑defects, smoothing surfaces, and creating a naturally bright, healthy appearance that research shows can be more effective than traditional whitening approaches.

Microbiome Support: Reducing Harmful Bacteria

Beyond rebuilding teeth, nano‑hydroxyapatite actively supports oral health by reducing harmful bacterial colonisation—creating an environment where healthy teeth can thrive naturally.

• Pawinska et al., 2024 — Meta‑analysis of studies where people wore enamel samples in their mouths showed hydroxyapatite significantly reduced bacterial load by an average of 65% compared to negative controls. Study Link
• Ionescu et al., 2020 — Laboratory study found substituted nano‑hydroxyapatite toothpastes significantly reduced early bacterial colonisation and biofilm formation, with effects most pronounced at 12 hours—suggesting twice‑daily use provides optimal protection against harmful bacteria. Study Link

The Complete Science: Why Nano‑Hydroxyapatite Works

The beauty of nano‑hydroxyapatite lies in its biomimetic nature—it's essentially the same mineral that makes up 97% of tooth enamel, allowing it to integrate seamlessly with natural tooth structure.

Safety for All Ages: The Fluoride‑Free Advantage

Perhaps most importantly, nano‑hydroxyapatite offers all these benefits with naturally safe active ingredients if accidentally swallowed—making it the ideal choice for children and families who prefer fluoride‑free oral care. While we recommend spitting out toothpaste after brushing (as with any oral care product), parents can have peace of mind knowing the active ingredients are naturally safe.

Proven Long‑Term Caries Protection

Clinical research demonstrates that xylitol provides remarkable long‑term protection against cavities, with benefits that can last up to two years even after stopping use—making it an exceptional preventive ingredient.

• Janakiram et al., 2017 — Comprehensive systematic review and meta‑analysis of 20 clinical studies found xylitol significantly reduces the incidence of cavities and serves as an effective self‑applied preventive agent. The review confirmed xylitol's unique mechanism of disrupting harmful bacteria's energy production, leading to "a futile energy consumption cycle and cell death." Study Link
• Riley et al., 2015 — This prestigious Cochrane review found that fluoride toothpaste containing xylitol may reduce tooth decay in permanent teeth by 13% over 3 years compared to fluoride‑only toothpaste, concluding that the combination "may be more effective than fluoride‑only toothpaste for preventing caries." Study Link

Superior Plaque Control: Direct Anti‑Microbial Action

Unlike passive sweeteners, xylitol actively fights the bacterial biofilm that causes both cavities and gum disease—providing a dual benefit for comprehensive oral health through its unique bacterial‑starving mechanism.

• Nasseripour et al., 2022 — Meta‑analysis of eight studies found that chewing xylitol gum "significantly reduced plaque quantity" compared to other gums. This plaque reduction stems from xylitol's "direct anti‑microbial effect on growth and accumulation of the biofilm," providing benefits for both cavity prevention and gum health. Study Link
• Söderling & Pienihäkkinen, 2025 — Recent systematic review comparing xylitol to other sugar alcohols found "the best evidence of specific beneficial effects for xylitol gum" in reducing harmful bacteria and plaque. Unlike sorbitol, xylitol consistently and significantly lowered cavity‑causing bacteria, confirming its unique benefits. Study Link

Dosage Matters: The Key to Effectiveness

Research reveals that xylitol's effectiveness is dose‑dependent, with higher concentrations providing more significant benefits—crucial information for choosing effective xylitol‑containing products.

Beyond Sugar Substitution: Unique Benefits

What sets xylitol apart from other sugar‑free sweeteners is its proven active benefits—it's not just avoiding harm, but actively promoting oral health through targeted bacterial intervention that other polyols simply can't match.

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